Biological Engineering (BIOE)

BIOE 199, SPECIAL TOPICS, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 240, A PRACTICAL INTRODUCTION TO BIOMEDICAL SIGNALS AND SENSORS, 3 Credits

Provides the biophysical basis for several medically-important signals, the operating principles of specific sensors used for acquiring those biomedical signals, and an introduction to signal acquisition, processing, and interpretation in the context of those biosignals. Emphasizes conceptual understanding of these topics through active engagement in group discussions, assembling specific sensor systems using off-the-shelf electronics systems, and use of the sensors to acquire, process, and interpret biosignals.

BIOE 299, SPECIAL TOPICS, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 311, BIOENGINEERING THERMODYNAMICS, 3 Credits

Introduces thermodynamics as applied to biological and biophysical systems. Presents first and second law of thermodynamics, phase and reaction equilibria, and statistical thermodynamics in the context of molecular interactions, binding equilibria, metabolism, and biomolecular transport common to living systems. Explores the thermodynamics of macromolecules (including proteins and DNA).

Prerequisite: (MTH 256 with C or better or MTH 256H with C or better) and (CBEE 212 [C] or CBEE 212H [C] or CBEE 280 [C] or PH 315 [C] or CH 440 [C])

BIOE 331, BIOTRANSPORT I, 3 Credits

Introduces the concepts of mass and fluid transport in the context of problems of interest in bioengineering. Emphasizes conceptual understanding of both microscopic and macroscopic mass and momentum transport with a focus on how these processes work in the body.

Prerequisite: (MTH 256 with C or better or MTH 256H with C or better) and (CBEE 212 [C] or CBEE 212H [C] or CBEE 280 [C])

BIOE 340, BIOMEDICAL ENGINEERING PRINCIPLES, 3 Credits

Application of engineering concepts (mass and energy conservation, thermodynamics, and transport phenomena) to cellular- and system-level human physiology; design considerations for biomedical interventions and devices.

Prerequisite: BI 231 with C or better and BI 233 (may be taken concurrently) [C] and CBEE 213 (may be taken concurrently) [C] and (CHE 333 (may be taken concurrently) [C] or CHE 333H (may be taken concurrently) [C])

Recommended: Completion or concurrent enrollment in BI 233 and (CHE 333 or CHE 333H)

BIOE 351, BIOMATERIALS AND BIOINTERFACES, 3 Credits

Material interactions with human tissue, with emphasis on the role of interfacial chemistry and physics in cell adhesion, infection, blood coagulation and thrombosis. Preparation of functional hydrogels, material coatings, and derivitizations, including immobilized bio-active molecules. Issues surrounding regulation of implants and device failure.

Prerequisite: (BB 451 (may be taken concurrently) with C or better or BB 451H (may be taken concurrently) with C or better) and (CHE 333 (may be taken concurrently) [C] or CHE 333H (may be taken concurrently) [C])

BIOE 399, SPECIAL TOPICS, 0-16 Credits

Equivalent to: BIOE 399H

This course is repeatable for 16 credits.

BIOE 401, RESEARCH, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 403, THESIS, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 405, READING AND CONFERENCE, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 406, PROJECTS, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 407, SEMINAR, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 415, BIOENGINEERING LABORATORY, 3 Credits

Laboratory experimentation with unit operations and processes in bioengineering; preparation of technical reports.

Prerequisite: CBEE 414 with C or better

BIOE 420, SOCIAL JUSTICE, ETHICS, AND ENGINEERING, 3 Credits

Examination of difference, power, and discrimination in engineering education and practice. Lec/rec.

Prerequisite: CBEE 320 with C or better

BIOE 440, BIOCONJUGATION, 3 Credits

Survey of theory and practical current methods for chemical modification and conjugation of proteins and other biomolecules. Topics include permanent and cleavable cross-linkers, protein modification reagents, immobilization of enzymes/DNA, enzyme-antibody conjugates, protein-protein interactions, PEGylation and labeling of proteins, and solid-phase peptide synthesis.

Prerequisite: BB 450 with C or better

BIOE 445, SURFACE ANALYSIS, 3 Credits

The characterization of molecular, biological, and engineered surfaces by modern surface analytical techniques. Topics include surface sensitive modes of electron spectroscopy, vibrational spectroscopy, and mass spectrometry. Students will interpret surface analytical data and gain access to the surface science literature.

Prerequisite: BIOE 351 (may be taken concurrently) with C or better

BIOE 457, BIOREACTORS, 3 Credits

Design and analysis of bioreactors using suspension and immobilized microbial cultures.

Prerequisite: (BB 451 with C or better or BB 451H with C or better) and (CHE 333 [C] or CHE 333H [C])

BIOE 459, CELL ENGINEERING, 3 Credits

Application of engineering methods and principles to the study of mammalian cells. Emphasis on mathematical models of cellular processes (e.g., cellular mass transport, protein-ligand interactions, cellular mechanics) and methods for probing the physical characteristics of biological molecules and cells.

Prerequisite: (BB 451 with C or better or BB 451H with C or better) and (CHE 333 [C] or CHE 333H [C])

Recommended: BB 451 and CHE 333

BIOE 462, BIOSEPARATIONS, 3 Credits

Application of basic mass transfer, reaction kinetics and thermodynamic principles to understanding, selection, and development of strategies for the recovery of products from bioreactors.

Prerequisite: (BB 451 with C or better or BB 451H with C or better) and (CHE 333 [C] or CHE 333H [C])

BIOE 465, BIOMEDICAL IMAGE PROCESSING, 3 Credits

Explores fundamentals of image formation, enhancement, and analysis for medical and biological applications. Presents common medical imaging and biomedical diagnostic imaging types and resultant format. Provides opportunity to work with real image sets to perform enhancement and analysis operations for the purpose of increasing diagnostic specificity and sensitivity as well as extracting quantitative information.

Prerequisite: BIOE 350 with C or better

BIOE 490, BIOENGINEERING PROCESS DESIGN, 4 Credits

Engineering economic analysis. Design of bioprocesess: Development of process flow diagrams, equipment sizing, operation, and safety. Quality control and FDA regulations. Lec/rec.

Prerequisite: BIOE 415 with C or better and BIOE 457 [C] and BIOE 462 [C]

BIOE 491, BIOENGINEERING PRODUCT DESIGN, 4 Credits

Design of biomedical and biotechnology-based products by a structured design process that considers customer and regulatory needs.

Prerequisite: BIOE 340 with C or better and (BB 451 [C] or BB 451H [C])

BIOE 492, BIOENGINEERING CAPSTONE DESIGN, 4 Credits

Culminating experience in bioengineering design of processes and devices. Includes capstone project prototyping, testing and documentation, and constraints in ethics, intellectual property, standards, regulatory, and manufacturing.

Prerequisite: BIOE 491 with C or better

BIOE 495, ^BIOENGINEERING PRODUCT DESIGN, 4 Credits

Emphasizes design of biomedical and biotechnology-based products. Focuses on applying a structured design process, meeting customer needs and regulatory considerations to design. (Writing Intensive Course)

Attributes: CWIC – Core, Skills, WIC

Prerequisite: BIOE 240 with C or better and BIOE 332 [C] and BIOE 340 [C] and (BB 451 [C] or BB 451H [C])

BIOE 499, SPECIAL TOPICS, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 501, RESEARCH, 1-12 Credits

This course is repeatable for 12 credits.

BIOE 503, THESIS, 1-16 Credits

This course is repeatable for 999 credits.

BIOE 507, SEMINAR, 1 Credit

This course is repeatable for 3 credits.

BIOE 511, CELLULAR AND MOLECULAR BIOENGINEERING, 3 Credits

Fundamentals of mammalian cell biology, with an emphasis on biomedical applications and engineering approaches to study and manipulate cells and tissues.

Recommended: A working knowledge of cell biology and biochemistry

BIOE 512, MODELING OF PHYSIOLOGICAL SYSTEMS, 4 Credits

Integration of engineering principles and human physiology in the areas of: transport phenomena in the cardiopulmonary and renal systems, bioelectricity in the nervous system, and mechanics of the musculoskeletal system.

BIOE 513, DRUG & MEDICAL DEVICE REGULATIONS IN TECHNOLOGY DEVELOPMENT, 3 Credits

Explores the processes by which drugs and devices are regulated by the Food and Drug Administration. Covers drug and device classifications, regulatory processes for different classes of drugs and devices, current good manufacturing practices, and process validation.

Available via Ecampus

BIOE 520, SOCIAL JUSTICE, ETHICS, AND ENGINEERING, 3 Credits

Examination of difference, power, and discrimination in engineering education and practice. Lec/rec.

BIOE 540, BIOCONJUGATION, 3 Credits

Survey of theory and practical current methods for chemical modification and conjugation of proteins and other biomolecules. Topics include permanent and cleavable cross-linkers, protein modification reagents, immobilization of enzymes/DNA, enzyme-antibody conjugates, protein-protein interactions, PEGylation and labeling of proteins, and solid-phase peptide synthesis.

Recommended: BB 450

BIOE 545, SURFACE ANALYSIS, 3 Credits

The characterization of molecular, biological, and engineered surfaces by modern surface analytical techniques. Topics include surface sensitive modes of electron spectroscopy, vibrational spectroscopy, and mass spectrometry. Students will interpret surface analytical data and gain access to the surface science literature.

Recommended: BIOE 351

BIOE 557, BIOREACTORS, 3 Credits

Design and analysis of bioreactors using suspension and immobilized microbial cultures.

Recommended: (BB 451 or BB 451H) and (CHE 333 or CHE 333H)

BIOE 562, BIOSEPARATIONS, 3 Credits

Application of basic mass transfer, reaction kinetics and thermodynamic principles to understanding, selection, and development of strategies for the recovery of products from bioreactors.

Recommended: BB 451 and CHE 332

BIOE 599, SPECIAL TOPICS, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 601, RESEARCH, 1-16 Credits

This course is repeatable for 16 credits.

BIOE 603, THESIS, 1-16 Credits

This course is repeatable for 999 credits.