BIOE 199. SPECIAL TOPICS. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 299. SPECIAL TOPICS. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 340. BIOMEDICAL ENGINEERING PRINCIPLES. (3 Credits)

Application of engineering concepts (mass and energy conservation, thermodynamics, and transport phenomena) to cellular- and system-level human physiology; design considerations for biomedical interventions and devices.

Prerequisites: (BI 231 with C or better or Z 331 with C or better) and (CHE 332 [C] or CHE 332H [C])

BIOE 351. BIOMATERIALS AND BIOINTERFACES. (3 Credits)

Material interactions with human tissue, with emphasis on the role of interfacial chemistry and physics in cell adhesion, infection, blood coagulation and thrombosis. Preparation of functional hydrogels, material coatings, and derivitizations, including immobilized bio-active molecules. Issues surrounding regulation of implants and device failure.

Prerequisites: (BB 451 (may be taken concurrently) with C or better or BB 451H (may be taken concurrently) with C or better) and (CHE 333 (may be taken concurrently) [C] or CHE 333H (may be taken concurrently) [C])

BIOE 399. SPECIAL TOPICS. (0-16 Credits)

This course is repeatable for 16 credits.

BIOE 401. RESEARCH. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 403. THESIS. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 405. READING AND CONFERENCE. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 406. PROJECTS. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 407. SEMINAR. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 415. BIOENGINEERING LABORATORY. (3 Credits)

Laboratory experimentation with unit operations and processes in bioengineering; preparation of technical reports.

Prerequisites: CBEE 414 with C or better

BIOE 420. SOCIAL JUSTICE, ETHICS, AND ENGINEERING. (3 Credits)

Examination of difference, power, and discrimination in engineering education and practice. Lec/rec.

BIOE 440. BIOCONJUGATION. (3 Credits)

Survey of theory and practical current methods for chemical modification and conjugation of proteins and other biomolecules. Topics include permanent and cleavable cross-linkers, protein modification reagents, immobilization of enzymes/DNA, enzyme-antibody conjugates, protein-protein interactions, PEGylation and labeling of proteins, and solid-phase peptide synthesis.

Prerequisites: BB 450 with C or better

BIOE 445. SURFACE ANALYSIS. (3 Credits)

The characterization of molecular, biological, and engineered surfaces by modern surface analytical techniques. Topics include surface sensitive modes of electron spectroscopy, vibrational spectroscopy, and mass spectrometry. Students will interpret surface analytical data and gain access to the surface science literature.

Prerequisites: BIOE 351 with C or better

BIOE 457. BIOREACTORS. (3 Credits)

Design and analysis of bioreactors using suspension and immobilized microbial cultures.

Prerequisites: (BB 451 with C or better or BB 451H with C or better) and (CHE 333 [C] or CHE 333H [C])

BIOE 459. CELL ENGINEERING. (3 Credits)

Application of engineering methods and principles to the study of mammalian cells. Emphasis on mathematical models of cellular processes (e.g., cellular mass transport, protein-ligand interactions, cellular mechanics) and methods for probing the physical characteristics of biological molecules and cells.

BIOE 462. BIOSEPARATIONS. (3 Credits)

Application of basic mass transfer, reaction kinetics and thermodynamic principles to understanding, selection, and development of strategies for the recovery of products from bioreactors.

Prerequisites: BB 451 with C or better and (CHE 332 [C] or CHE 332H [C])

BIOE 470. REGULATION OF DRUGS AND MEDICAL DEVICES. (2 Credits)

Overview of regulations for pharmaceutical products and medical devices. Food and Drug Administration's approval process. Current good manufacturing practices and process validation is emphasized. Quality control and assurance, compliance, and important analytical methods will be introduced.

BIOE 490. BIOENGINEERING PROCESS DESIGN. (4 Credits)

Engineering economic analysis. Design of bioprocesess: Development of process flow diagrams, equipment sizing, operation, and safety. Quality control and FDA regulations. Lec/rec.

Prerequisites: CHE 333 with C or better or CHE 333H with C or better

Corequisites: BIOE 457

BIOE 491. BIOENGINEERING PRODUCT DESIGN. (4 Credits)

Design of biomedical and biotechnology-based products. Applications of a structured design process, meeting customer needs and regulatory considerations to design.

Prerequisites: BIOE 490 with C or better

BIOE 492. BIOENGINEERING CAPSTONE DESIGN. (4 Credits)

Culminating experience in bioengineering design of processes and devices. Includes capstone project prototyping, testing and documentation, and constraints in ethics, intellectual property, standards, regulatory, and manufacturing.

Prerequisites: BIOE 491 with C or better

BIOE 499. SPECIAL TOPICS. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 503. THESIS. (1-16 Credits)

Graded P/N.

This course is repeatable for 999 credits.

BIOE 507. SEMINAR. (1 Credit)

Graded P/N.

This course is repeatable for 3 credits.

BIOE 511. CELLULAR AND MOLECULAR BIOENGINEERING. (3 Credits)

Fundamentals of mammalian cell biology, with an emphasis on biomedical applications and engineering approaches to study and manipulate cells and tissues.

BIOE 513. DRUG AND MEDICAL DEVICE REGULATIONS IN TECHNOLOGY DEVELOPMENT. (2 Credits)

Overview of the processes by which drugs and devices are regulated by the Food and Drug Administration. Topics include drug and device classifications, approval routes for different classes of drugs and devices, current good manufacturing practices, process validation, and quality assurance and control.

BIOE 520. SOCIAL JUSTICE, ETHICS, AND ENGINEERING. (3 Credits)

Examination of difference, power, and discrimination in engineering education and practice. Lec/rec.

BIOE 540. BIOCONJUGATION. (3 Credits)

Survey of theory and practical current methods for chemical modification and conjugation of proteins and other biomolecules. Topics include permanent and cleavable cross-linkers, protein modification reagents, immobilization of enzymes/DNA, enzyme-antibody conjugates, protein-protein interactions, PEGylation and labeling of proteins, and solid-phase peptide synthesis.

BIOE 545. SURFACE ANALYSIS. (3 Credits)

The characterization of molecular, biological, and engineered surfaces by modern surface analytical techniques. Topics include surface sensitive modes of electron spectroscopy, vibrational spectroscopy, and mass spectrometry. Students will interpret surface analytical data and gain access to the surface science literature.

BIOE 557. BIOREACTORS. (3 Credits)

Design and analysis of bioreactors using suspension and immobilized microbial cultures.

BIOE 559. CELL ENGINEERING. (3 Credits)

Application of engineering methods and principles to the study of mammalian cells. Emphasis on mathematical models of cellular processes (e.g., cellular mass transport, protein-ligand interactions, cellular mechanics) and methods for probing the physical characteristics of biological molecules and cells.

BIOE 562. BIOSEPARATIONS. (3 Credits)

Application of basic mass transfer, reaction kinetics and thermodynamic principles to understanding, selection, and development of strategies for the recovery of products from bioreactors.

BIOE 599. SPECIAL TOPICS. (1-16 Credits)

This course is repeatable for 16 credits.

BIOE 603. THESIS. (1-16 Credits)

Graded P/N.

This course is repeatable for 999 credits.